Preheat the oven to 350°F (175°C). Lightly grease a 9×5-inch loaf pan or line it with parchment paper.
Mix the dry ingredients: In a medium bowl, whisk together the flour, baking soda, baking powder, salt, and pumpkin pie spice. Set aside.
Combine the wet ingredients: In a large bowl, whisk the eggs, granulated sugar, brown sugar, pumpkin puree, oil, milk, and vanilla extract until smooth and fully combined.
Add dry to wet: Gently fold the dry ingredients into the wet mixture using a spatula or wooden spoon. Mix just until no flour streaks remain—don’t overmix.
Add-ins (optional): Stir in chocolate chips, nuts, or other add-ins if using.
Transfer to pan: Pour the batter into the prepared loaf pan and smooth the top. If desired, sprinkle with pepitas.
Bake for 55–65 minutes, or until a toothpick inserted into the center comes out clean or with just a few moist crumbs.
Cool: Let the bread cool in the pan for 10–15 minutes, then transfer to a wire rack to cool completely before slicing.